Hemophagocytic syndrome associated with dengue ¿what is the cause?
DOI:
https://doi.org/10.56294/shp2024134Keywords:
Hemophagocytic lymphohistiocytosis, hemophagocytic syndrome, hemophagocytic syndrome associated with infection, pancytopenia, primary dengue infectionAbstract
Introduction: Hemophagocytic syndrome (HS) is a dysregulated immune response that causes severe systemic inflammation and can arise from a variety of conditions, including viral infections such as dengue. Although its immunological process has been studied, diagnostic and treatment protocols remain unclear, affecting patient survival and prognosis.
Methodology: A descriptive and retrospective study reviewing the literature of the last two decades to identify consensus on the causal relationship between HS and dengue. Fourteen articles were selected that demonstrated a causal relationship between the pathophysiological mechanisms of HS and dengue in pediatric and adult patients.
Results: A consensus was reached associating the uncontrolled inflammatory response of HUS with the pathophysiological processes of dengue in any of its stages, confirmable by studies (laboratory and anatomopathological), its relationship with risk factors to optimize treatments and prognosis.
Conclusion: Dengue in any of its stages can be a cause of HUS, but it is not the only entity capable of generating it.
References
1. Runge‐Ranzinger S, McCall PJ, Kroeger A, Horstick O. Dengue disease surveillance: an updated systematic literature review. Trop Med Int Health. 2014 Sep;19(9):1116–60.
2. Fietta P, Manganelli P. [The hemophagocytic syndrome (macrophage activation syndrome)]. Minerva Med. 2003 Feb;94(1):19–27.
3. Lei HY. Transient hemophagocytic activity in dengue immunopathogenesis. J Formos Med Assoc. 2009 Aug;108(8):595–8. doi:10.1016/s0929-6646(09)60379-x. PMID: 19666346.
4. Hein N, Bergara GH, Moura NBV, Cardoso DM, Hirose M, Ferronato AE, et al. Dengue fever as a cause of hemophagocytic lymphohistiocytosis. Autops Case Rep. 2015 Sep 30;5(3):33–6.
5. Brisse E, Wouters CH, Matthys P. Hemophagocytic lymphohistiocytosis (HLH): A heterogeneous spectrum of cytokine-driven immune disorders. Cytokine Growth Factor Rev. 2015 Jun;26(3):263–80.
6. Astigarraga I, Gonzalez-Granado LI, Allende LM, Alsina L. Síndromes hemofagocíticos: la importancia del diagnóstico y tratamiento precoces [Haemophagocytic syndromes: The importance of early diagnosis and treatment]. An Pediatr (Engl Ed). 2018 Aug;89(2):124.e1–8. doi:10.1016/j.anpedi.2018.05.003. PMID: 29871839.
7. Wan Jamaludin WF, Periyasamy P, Wan Mat WR, Abdul Wahid SF. Dengue infection associated hemophagocytic syndrome: Therapeutic interventions and outcome. J Clin Virol. 2015;69:91–5. doi:10.1016/j.jcv.2015.06.004.
8. Hein N, Bergara GH, Moura NBV, et al. Dengue fever as a cause of hemophagocytic lymphohistiocytosis. Autops Case Rep [Internet]. 2015;5(3):33–6. Disponible en: http://dx.doi.org/10.4322/acr.2015.016
9. Lu PL, Hsiao HH, Tsai JJ, Chen TC, Chen TP, Lin SF, Feng MC. Síndrome hemofagocítico asociado al virus del dengue y diseritropoyesis: reporte de un caso. Kaohsiung J Med Sci. 2005 Jan;21(1):34–8. doi:10.1016/S1607-551X(09)70274-8.
10. Nelson ER, Bierman HR, Chulajata R. Fagocitosis hematológica en médula ósea postmortem de fiebre hemorrágica por dengue. Am J Med Sci. 1966;252:68–74.
11. Rueda E, Méndez A, González G. Síndrome hemofagocítico asociado con dengue hemorrágico. Biomedica [Internet]. 2002 Jun 1 [citado 2024 Oct 20];22(2):160–6. Disponible en: https://revistabiomedica.org/index.php/biomedica/article/view/1155
12. Pérez-Sánchez ML, et al. Síndrome hemofagocítico asociado a dengue grave en una institución pediátrica de Cali - Colombia. Infectio. 2023;27(1):3–6.
13. Simon AC, Delhi Kumar CG, Basu D, Ramesh Kumar R. Hemophagocytic lymphohistiocytosis in children: Clinical profile and outcome. J Pediatr Hematol Oncol. 2020;42(5):e281–5.
14. Bhattacharya D, Angurana SK, Nallasamy K, Iyer R, Jayashree M. Severe dengue and associated hemophagocytic lymphohistiocytosis in PICU. Indian J Pediatr. 2019 Dec;86(12):1094–8
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Copyright (c) 2024 Natalia Araujo Jaramillo, Diego Balcarce (Author)
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