Cocaine use during pregnancy and its relationship with eclampsia: an interdisciplinary approach
DOI:
https://doi.org/10.56294/shp2025200Keywords:
cocaine, pregnancy, eclampsia, detection, interdisciplinary workAbstract
In Argentina, the prevalence of cocaine use among pregnant women varied according to the studies carried out and the methodologies applied. The detection of these cases was probably underestimated due to the social stigma and the lack of adequate screening tools. The ASSIST test was promoted as a method to improve the early identification of use. The use of cocaine during pregnancy was associated with an increase in the occurrence of hypertensive disorders, including preeclampsia and eclampsia. The mechanisms involved included uterine vasospasms, oxidative stress and reduced blood flow to the foetus, which led to serious consequences such as placental infarctions and premature births. Faced with this problem, the Argentine health system adopted an interdisciplinary approach, with the involvement of doctors, psychologists, social workers and other professionals. Early detection in prenatal check-ups was promoted, as well as the training of health teams. The treatment was designed to be comprehensive, including psychosocial therapies and medical support. After delivery, long-term follow-up was recommended to guarantee the well-being of the mother-child pair and prevent relapses or future consequences. This situation represented a major challenge for public health, underlining the urgency of implementing effective detection, treatment and support strategies.
References
1. Ahamohammadi A, Zafari M. Crack abuse during pregnancy: maternal, fetal and neonatal complication. J Matern Fetal Neonatal Med. 2016;29(5):795-7. Available from: https://pubmed.ncbi.nlm.nih.gov/25747949/
2. Blayac L, Ponte C, Lavaud M, Micallef J, Lapeyre-Mestre. Increase of cannabis and cocaine use by pregnant women in France from 2005 to 2018: Insights of the annual cross sectional OPPIDUM survey. Therapie. 2023 Mar-Apr;78(2):201-11. Available from: https://pubmed.ncbi.nlm.nih.gov/36283856/
3. Chang G. Substance use during pregnancy: Overview of selected drugs. 2021. Available from: https://www.uptodate.com/contents/substance-use-during-pregnancy-overview-of-selected-drugs
4. Cook JL, Green CR, de la Ronde S, et al. Epidemiology and Effects of Substance Use in Pregnancy. J Obstet Gynaecol Can. 2017;39(10):906-15. Available from: https://pubmed.ncbi.nlm.nih.gov/28935056/
5. Dutra AGR, Oliveira AG de, Carneiro BAP, Medeiros EC, Veiga KGC, Lima RSG, et al. Complicações gestacionais relacionadas ao uso de drogas por gestantes. Rev Acervo Mais. 2021;35:e8702. Available from: https://acervomais.com.br/index.php/cientifico/article/view/8702
6. Elkafrawi D, Sisti G, Araji S, Khoury A, Miller J, Rodriguez Echevarria B. Risk Factors for Neonatal/Maternal Morbidity and Mortality in African American Women with Placental Abruption. Medicina (Kaunas). 2020;56(4):174. Available from: https://pubmed.ncbi.nlm.nih.gov/32295061/
7. Garrison-Desany HM, Ladd-Acosta C, Hong X, et al. Addressing the smoking-hypertension paradox in pregnancy: insight from a multiethnic US birth cohort. Precis Nutr. 2023;2(2):e00035. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312115/
8. Gorelick DA. Cocaine use disorder in adults: Epidemiology, pharmacology, clinical manifestations, medical consequences, and diagnosis. 2021. Available from: https://www.uptodate.com/contents/cocaine-use-disorder-in-adults-epidemiology-pharmacology-clinical-manifestations-medical-consequences-and-diagnosis
9. Hetea A, Cosconel C, Stanescu AAM, Simionescu AA. Alcohol and Psychoactive Drugs in Pregnancy. Maedica (Bucur). 2019;14(4):397-401. Available from: https://pubmed.ncbi.nlm.nih.gov/32153672/
10. Hoang T, Czuzoj-Shulman N, Abenhaim HA. Pregnancy outcome among women with drug dependence: A population-based cohort study of 14 million births. J Gynecol Obstet Hum Reprod. 2020;49(7):101741. Available from: https://pubmed.ncbi.nlm.nih.gov/32438133/
11. Jarlenski M, Krans EE, Chen Q, et al. Substance use disorders and risk of severe maternal morbidity in the United States. Drug Alcohol Depend. 2020;216:108236. Available from: https://pubmed.ncbi.nlm.nih.gov/32846369/
12. Jenabi E, Salimi Z, Bashirian S, Khazaei S, Ayubi E. The risk factors associated with placenta previa: An umbrella review. Placenta. 2022;117:21-7. Available from: https://pubmed.ncbi.nlm.nih.gov/34768164/
13. Moraes Castro M, Pinto F, Pereiras C, Fischer A, Vogel C, Duarte V, et al. Autodeclaración del consumo de marihuana, tabaco, alcohol y derivados de cocaína en embarazadas en 2013 y 2016, Montevideo, Uruguay. Adicciones. 2020;32(3):173-80. Available from: https://www.adicciones.es/index.php/adicciones/article/view/1107/1020
14. Naciones Unidas. Claves del Informe Mundial sobre Drogas: récord de consumo de cocaína y nuevos opioides sintéticos. 2024. Available from: https://news.un.org/es/story/2024/06/1530826
15. Salemi JL, Raza SA, Modak S, Fields-Gilmore JAR, Mejia de Grubb MC, Zoorob RJ. The association between use of opiates, cocaine, and amphetamines during pregnancy and maternal postpartum readmission in the United States: A retrospective analysis of the Nationwide Readmissions Database. Drug Alcohol Depend. 2020;210:10796. Available from: https://pubmed.ncbi.nlm.nih.gov/32278846/
16. Samudio Domínguez GC, Correa A, Brítez Martínez IC, Vera Quintana LM, Ortiz Cuquejo LM. Frecuencia de consumo de drogas adictivas ilícitas en gestantes o puérperas y su detección en recién nacidos en un hospital materno-infantil de Asunción. Pediatr (Asunción). 2023;50(1):48-57. Available from: https://www.revistaspp.org/index.php/pediatria/article/view/747
17. Silva Moreira DJ, Santos IM, Azevedo Dunningham W. A exposição ao crack durante a gestação e suas repercussões maternas, fetais e neonatais: uma revisão sistemática. Rev Neuropsiq. 2022;26(3):84-90. Available from: https://www.revneuropsiq.com.br/rbnp/article/view/946
18. Veras Eloy Santos J, Fonseca da Silva NA, Marcolela Andreoli Sartes L, Bohrer Schuch J, Paim Kessler FH, Barbosa Terra M. Psychiatric and obstetric characteristics of pregnant crack users admitted to a referral center in Southern Brazil. J Addict Dis. 2023. Available from: https://pubmed.ncbi.nlm.nih.gov/38047869/
19. Villarreal M, Belmonte V, Olivares JL, Abdala A. Health trajectories of women who used cocaine and/or cannabis during pregnancy. Retrospective cohort study in La Pampa, Argentina. [Spanish] Rev Fac Cien Med Univ Nac Cordoba. 2020 May 10;77(2):79-85. Available from: https://pubmed.ncbi.nlm.nih.gov/32558509/.
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