Alzheimer's disease as a neurodegenerative manifestation of type 2 diabetes
DOI:
https://doi.org/10.56294/shp2025204Keywords:
Diabetes Mellitus, Alzheimer's, neurodegeneration, insulin resistance, treatmentAbstract
The research addressed the relationship between Type 2 Diabetes Mellitus (DM2) and Alzheimer's disease, two pathologies of high prevalence and impact. Although traditionally considered independent diseases, they were shown to share common pathophysiological mechanisms such as insulin resistance, oxidative stress and chronic inflammation. Scientific evidence allowed the hypothesis of Alzheimer's as a possible ‘type 3 diabetes’ to be proposed, highlighting the implication of genetic factors, such as the ε4 allele of the APOE gene. In addition, antidiabetic therapies with neuroprotective potential, such as intranasal insulin and metformin, were analysed. This complex and multifactorial relationship offered new therapeutic and preventive perspectives for both diseases, especially in older adults.
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Copyright (c) 2025 Rocío Soledad Meza Maceiras, Karina Bustamante Galarza (Author)
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