Systematic review: Microbiota And Chronic Inflammatory Diseases In Young Adults
DOI:
https://doi.org/10.56294/shp2025215Keywords:
Microbiota, chronic inflammatory diseases, young adults, dysbiosis, probioticsAbstract
Introduction: The gut microbiota plays a pivotal role in human health, influencing digestion, vitamin synthesis, and immune regulation. Dysbiosis, or microbiota imbalance, is linked to chronic inflammatory diseases (CIDs), such as Crohn's disease and ulcerative colitis. Factors including genetics, environmental influences, and high-fat Western diets contribute to the prevalence of these conditions, particularly among young adults (18–35 years) in Argentina.
Objectives: This study aims to examine the relationship between gut microbiota and CIDs in young adults in Argentina. It seeks to identify risk factors and dysbiosis patterns by:
●Characterizing microbial composition,
●Identifying dietary and environmental influences,
●Correlating dysbiosis with inflammation and symptom severity, and
●Proposing therapeutic interventions.
Materials and Methods: This systematic review follows the PRISMA methodology.
●Population: Young adults with CIDs reported in studies from 2015 to 2024.
●Variables: Microbiota composition, inflammatory markers, dietary and environmental factors, and probiotic use.
●Analysis: Data will be extracted and visualized through graphs and tables, with an assessment of the quality of selected studies.
Results: The study aims to identify dysbiosis patterns and their association with environmental factors. It will also evaluate the effectiveness of probiotic interventions in improving symptoms and enhancing the quality of life for CID patients.
Conclusions: This research underscores the significance of gut microbiota as both a diagnostic and therapeutic tool. It aims to propose personalized strategies that could be incorporated into public health policies to mitigate the impact of CIDs.
References
Li X, Wang E, Tian H, Yang H, Gao Y, Chen Y, et al. Causal relationship between gut microbiota and autoimmune diseases: a two-sample Mendelian randomization study. Front Immunol. 2022;13:851407. Disponible en: https://pubmed.ncbi.nlm.nih.gov/35140703/
Sebastián-Domingo JJ, Sánchez-Sánchez C. De la flora intestinal al microbioma. Rev Esp Enferm Dig. 2018;110(1):51-9. Disponible en: https://scielo.isciii.es/scielo.php?pid=S1130-01082018000100009&script=sci_arttext
Ng SC, Bernstein CN, Vatn MH, et al. Disorders of a modern lifestyle: reconciling the epidemiology of inflammatory bowel diseases. Nat Rev Gastroenterol Hepatol. 2008;5(12):706-13. Disponible en: https://pubmed.ncbi.nlm.nih.gov/18515412/
Adolph TE, Tilg H. Western diets and chronic diseases. Nat Med. 2024;30(8):2133-47.
Franzosa EA, Sirota-Madi A, Avila-Pacheco J, et al. The gut microbiota in inflammatory bowel disease. Nat Microbiol. 2022;7(3):280-94. Disponible en: https://pubmed.ncbi.nlm.nih.gov/35273921/
Burisch J, Munkholm P. The epidemiology of inflammatory bowel disease. Scand J Gastroenterol. 2015;50(8):942-51.
Becattini S, Taur Y, Pamer EG. Antibiotics as major disruptors of gut microbiota. Front Cell Infect Microbiol. 2020;10:572912. Disponible en: https://www.frontiersin.org/articles/10.3389/fcimb.2020.572912/full
Baigrie D, Tilgner J, Heuschen P, et al. High ulcerative colitis and Crohn’s disease ratio in a population-based registry from Córdoba, Argentina. World J Gastroenterol. 2021;27(4):312-20. Disponible en: https://pubmed.ncbi.nlm.nih.gov/33531211/
Martin HM, Campbell BJ, Hart CA, et al. Escherichia coli pathobionts associated with inflammatory bowel disease. Clin Microbiol Rev. 2018;31(1):e00060-18. Disponible en: https://journals.asm.org/doi/full/10.1128/cmr.00060-18
Lopez-Siles M, Enrich-Capo N, Aldeguer X, Sabat-Mir M, Duncan SH, Garcia-Gil LJ. Mucosa-associated Faecalibacterium prausnitzii phylotype richness is reduced in patients with inflammatory bowel disease. Appl Environ Microbiol. 2015;81(21):7582-92. Disponible en: https://journals.asm.org/doi/full/10.1128/aem.02006-15
Lee RM, Smith PB, Cohen RD. Continued statural growth in older adolescents and young adults with Crohn’s disease and ulcerative colitis beyond the time of expected growth plate closure. Inflamm Bowel Dis. 2020;26(12):1880-5. Disponible en: https://academic.oup.com/ibdjournal/article/26/12/1880/5714217
Burisch J, Jess T. Environmental and genetic factors in the pathogenesis of inflammatory bowel disease. Gastroenterol Rev. 2018;32(2):151-62. Disponible en: https://journals.viamedica.pl
Lopez-Siles M, Duncan SH, Garcia-Gil LJ, Martinez-Medina M. Faecalibacterium prausnitzii: from microbiology to diagnostics and prognostics. ISME J. 2020;33(1):e00123-19. Disponible en: https://cmr.asm.org
Franzosa EA, Sirota-Madi A, Avila-Pacheco J, et al. Gut microbiota alterations in inflammatory bowel disease. J Crohns Colitis. 2020;14(8):1253-63. Disponible en: https://academic.oup.com
Schirmer M, Garner A, Vlamakis H, Xavier RJ. Microbial genes and pathways in inflammatory bowel disease. Clin Microbiol Rev. 2018;31(4):e00060-18. Disponible en: https://journals.asm.org
Wang T, Cai G, Qiu Y, et al. Structural segregation of gut microbiota between colorectal cancer patients and healthy volunteers. ISME J. 2020;14:1027-38.
Wilson BC, Vatanen T, Cutfield WS, O’Sullivan JM. The super-donor phenomenon in fecal microbiota transplantation. Front Cell Infect Microbiol. 2019;9:2.
Zuo T, Ng SC. The gut microbiota in the pathogenesis and therapeutics of inflammatory bowel disease. Front Microbiol. 2018;9:2247.
Jangi S, Gandhi R, Cox LM, et al. Alterations of the human gut microbiome in multiple sclerosis. Nat Commun. 2016;7:12015.
Sonnenburg JL, Bäckhed F. Diet–microbiota interactions as moderators of human metabolism. Nature. 2016;535(7610):56-64.
Turnbaugh PJ, Hamady M, Yatsunenko T, et al. A core gut microbiome in obese and lean twins. Nature. 2009;457(7228):480-4.
Published
Issue
Section
License
Copyright (c) 2025 Emanuel Zenon Aviza Joaquín, Daniel Nestor Chiacchiara (Author)
This work is licensed under a Creative Commons Attribution 4.0 International License.
The article is distributed under the Creative Commons Attribution 4.0 License. Unless otherwise stated, associated published material is distributed under the same licence.
