Hematological Alterations in Patients with COVID-19
DOI:
https://doi.org/10.56294/shp2025242Keywords:
COVID-19, lymphocytopenia, cytokine storm, thrombosisAbstract
Currently, the global population is under siege from COVID-19, a disease caused by the SARS-CoV-2 coronavirus, which has been declared a pandemic by the World Health Organization. COVID-19 usually presents with mild respiratory symptoms but is also associated with less common and somewhat delayed clinical manifestations such as thrombotic events (arterial or venous), skin inflammation, vasculitis, and the development of pulmonary fibrosis.
A literature review was conducted with the aim of characterizing hematological changes in patients during COVID-19. A total of 23 bibliographic references were reviewed, including books, journals, and websites from the Scielo and Infomed platforms.
It was found that the main hematological alterations caused by COVID-19 include lymphocytopenia, increased D-dimer, thrombocytopenia, platelet deficiency, and thrombosis, all of which are favored by the cytokine storm.
References
Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The Lancet. 2020 Feb 15; 395(10223):497–506.
Drosten C, Günther S, Preiser W, van der Werf S, Brodt H-R, Becker S, et al. Identification of a novel coronavirus in patients with severe acute respiratory syndrome. N Engl J Med. 2020 May 15; 348(20):1967–76.
Zaki AM, van Boheemen S, Bestebroer TM, Osterhaus ADME, Fouchier RAM. Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. N Engl J Med. 2018 Nov 8; 367(19):1814–20.
Naming the coronavirus disease (COVID-19) and the virus that causes it [Internet]. 2020 [Citado 3 May 2022]. Disponible en: https://www.who.int/emergencies/diseases/novel-coronavirus-2019/
Espinoza GI, Granja Morán M, Heredia Fuemayor M, Leon Amijos C, Orquera Carranco A et al. CONSENSO DE RECOMENDACIONES DE HEMATOLOGÍA SOBRE EL TRATAMIENTO DE COVID19. [Internet]. MTT2-PRT-0022. Versión 2.0. Ecuador. [Jul 2020; 8 May 2022]. Disponible en: https://www.google.com/url?sa=t&source=web&rct=j&url=https://www.salud.gob.ec/wp-content/uploads/2020/07/2.0-Conseso-de-recomendaciones-de-Hematolog%25C3%25ADa-sobre-el-tratamiento-de-COVID-19-1.pdf&ved=2ahUKEwjC_tHyh7nyAhWGVTABHULcAOoQFnoECAMQAQ&usg=AOvVaw3Ct8dkVOQoQUOLeS20P1fi
Estadísticas mundiales de casos confirmados con Covid-19. Statista [Internet]. 2021. [citado 1 Jun 2022]. Disponible en: https://es.statista.com/estadisticas/1104227/numero-acumulado-de-casos-de-coronavirus-covid-19-en-el-mundo-enero-marzo/
Estadísticas mundiales de muertes por Covid-19. Statista [Internet]. 2021. [citado 8 May 2022]. Disponible en: https://es.statista.com/estadisticas/1095779/numero-de-muertes-causadas-por-el-coronavirus-de-wuhan-por-pais/
Estadísticas en América Latina. Statista [Internet]. 2021. [citado 8 May 2022]. Disponible en: https://es.statista.com/estadisticas/1105121/numero-casos-covid-19-america-latina-caribe-pais/
Sitio Oficial del Ministerio de Salud Pública de Cuba. [Internet].2021 [citado 14 May 2022]. Disponible en: https://salud.msp.gob.cu/parte-de-cierre-del-dia-3-de-agosto-a-las-12-de-la-noche-2/
Casos confirmados en Villa Clara. CMHW [Internet]. 2021. [citado 8 May 2022]. Disponible en: https://www.cmhw.cu/en-villa-clara/35139-suma-villa-clara-723-casos-positivos-a-la-covid-19
Hernández-Rodríguez J, Prieto-González S, Ríos-Garcés R, Lledó G, Araujo O, Espígol-Frigolé G, Espinosa G. Respuesta inmunoinflamatoria en la COVID-19. En: Cervera R, Espinosa G, Ramos-Casals M, Hernández-Rodríguez J, Prieto-González S. Enfermedades Autoinmunes Sistémicas. Diagnóstico y tratamiento [Internet]. 6a ed. Barcelona: Editorial Médica Panamericana; 2020. 1-22. [citado 18 May 2022]. Disponible en: https://www.google.com/url?sa=t&source=web&rct=j&url=http://seciss.facmed.unam.mx/wp-content/uploads/2021/01/1_4936247548705767702.pdf&ved=2ahUKEwiAhv_atbryAhUbSzABHeBuCeoQFnoECBcQAQ&usg=AOvVaw3ezLowL7DLNFMeElLC4iTz&cshid=1629284516028
Besalduch J. Alteraciones hematológicas y COVID-19. Medicina Balear [Internet]. 2020 [citado 13 May 2022]; 35 (4): 69-73. Disponible en: https://www.google.com/url?sa=t&source=web&rct=j&url=http://ibdigital.uib.es/greenstone/sites/localsite/collect/medicinaBalear/index/assoc/Medicina/_Balear_/2020_v35/_n4p069.dir/Medicina_Balear_2020_v35_n4p069.pdf&ved=2ahUKEwiQvrnDtrryAhXZGFkFHWo5BR8QFnoECCIQAQ&usg=AOvVaw3aUs_V9A1RDXPauOu2BZSk
González Fajardo I, Linares Guerra EM, Diaz Padilla D, Lodoy Lóriga LM, Núñez Betancourt A. Cambios en variables hematológicas y velocidad de sedimentación globular de pacientes no críticos con la COVID-19. Rev Cienc Méd P del Río [Internet]. 2020 [citado 3 May 2022]; 24(3):e4515. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1561-31942020000300009
Villa Palacio MI, López Henao E. Alteraciones hematológicas en COVID-19. Nova [Internet]. 2020 [citado 7 May 2022]; 18 (spe35): 75-79. Disponible en: http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S1794-24702020000300075&lng=en.
Alvarado Amador I, Bandera Anzaldo J, Carreto Binaghi LE, Pavón Romero GF, Alejandre García A. Etiología y fisiopatología del SARS-CoV-2. Rev Latin Infect Pediatr [Internet]. 2020 [citado 13 May 2022]; 33 (s1): s5-s9. Disponible en: https://www.google.com/url?sa=t&source=web&rct=j&url=https://www.medigraphic.com/pdfs/infectologia/lip-2020/lips201b.pdf&ved=2ahUKEwj1gK7mtMLyAhVqRzABHe3tAnQQFnoECAsQAQ&usg=AOvVaw2GqtnoAojTw61raelO6Ls9
Serra Valdés MA. COVID-19. De la patogenia a la elevada mortalidad en el adulto mayor y con comorbilidades. Rev haban cienc méd [Internet]. 2020 [citado 13 May 2022]; 19(3):e3379. Disponible en: http://www.revhabanera.sld.cu/index.php/rhab/article/view/3379
Zamora González Y. Infección por SARS-CoV-2 y sus efectos sobre el sistema de la coagulación. Rev Cub Hematol, Inmun y Hematot [Internet]. 2020 [citado 13 May 2022];36:e1303. Disponible en: https://www.google.com/url?sa=t&source=web&rct=j&url=http://www.revhematologia.sld.cu/index.php/hih/article/download/1303/955&ved=2ahUKEwjM5oSVtcLyAhX-SzABHQTaByMQFnoECAcQAQ&usg=AOvVaw2bi3rRBCjspERaVNAs7c90
Guan WJ, Ni ZY, Hu Y, et al. Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med. 2020.
Wu C, Chen X, Cai Y, et al. Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China. JAMA Intern Med. 2020.
Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020; 395(10223): 497-506.
Wang D, Hu B, Hu C, et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA. 2020.
Qu R, Ling Y, Zhang YH, et al. Platelet-to-lymphocyte ratio is associated with prognosis in patients with coronavirus disease-19. J Med Virol. 2020.
Ciceri F, Beretta L, Scandroglio AM, Colombo S, Landoni G, Ruggeru A, et al. Microvascular COVID-19 lung vessels obstructive thromboinflammatory syndrome (MicroCLOTS):jAn atypical acute respiratory distress syndrome worjing hypothesis. Crit Care Resusc. 2020
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