Heyde’s Syndrome: A Case Report
DOI:
https://doi.org/10.56294/shp2024397Keywords:
gastrointestinal bleeding, severe aortic stenosisAbstract
Heyde’s syndrome is the association between aortic valve stenosis and gastrointestinal bleeding due to intestinal angiodysplasia. The pathophysiological basis of this syndrome appears to be an acquired deficiency of von Willebrand factor, leading to bleeding from angiodysplastic arteriovenous malformations. Treatment options include localization and cauterization of the bleeding sites, although this therapeutic approach is associated with a high recurrence rate. Aortic valve replacement appears to offer the best long-term resolution of bleeding and should be considered in most cases.
References
Heyde EC. Gastrointestinal bleeding in aortic stenosis. N Engl J Med. 1958;259:196.
Warkentin TE, Moore JC, Morgan DG. Aortic stenosis and bleeding gastrointestinal angiodysplasia: is acquired von Willebrand’s disease the link? Lancet. 1992;340(8810):35–7.
Morishima A, Marui A, Shimamoto T, Saji Y, Tambara K, Nishina T, et al. Successful aortic valve replacement for Heyde syndrome with confirmed hematologic recovery. Ann Thorac Surg. 2007;83(1):287–8.
Pate GE, Chandavimol M, Naiman SC, Webb JG. Heyde’s syndrome: a review. J Heart Valve Dis. 2004;13(5):701–12.
Vaz A, Correia A, Martins B, Capelo J, Ferreira P, Henriques P, et al. Heyde syndrome: The link between aortic stenosis and gastrointestinal bleeding. Rev Port Cardiol. 2010;29(2):309–14.
Veyradier A, Balian A, Wolf M, Giraud V, Montembault S, Obert B, et al. Abnormal von Willebrand factor in bleeding angiodysplasias of the digestive tract. Gastroenterology. 2001;120:346–53.
Vincentelli A, Susen S, Le Tourneau T, Six I, Fabre O, Juthier F, et al. Acquired von Willebrand syndrome in aortic stenosis. N Engl J Med. 2003;349(4):343–9.
Thompson JL, Schaff HV, Dearani JA, Park SJ, Sundt TM, Suri RM, et al. Risk of recurrent gastrointestinal bleeding after aortic valve replacement in patients with Heyde syndrome. J Thorac Cardiovasc Surg. 2012;144(1):112–6.
Godino C, Lauretta L, Pavon AG, Mangieri A, Viani G, Chieffo A, et al. Heyde’s syndrome incidence and outcome in patients undergoing transcatheter aortic valve implantation. J Am Coll Cardiol. 2013;61(6):687–9.
Figuinha FCR, Spina GS, Tarasoutchi F. Heyde’s syndrome: case report and literature review. Arq Bras Cardiol. 2011;96(3):e42–5.
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Copyright (c) 2024 Aline Aparecida Pacheco , Analía Claudia Sabattini (Author)
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